BD Phoenix™ M50 Automated Microbiology System
Marries performance with ease of use to provide timely and accurate identification and susceptibility testing results.1-6
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With an extensive panel well count and antimicrobial selection, true doubling dilutions, and extended dilutions for lowering breakpoints, the BD Phoenix™ M50 Automated Microbiology System marries performance with ease of use to provide the timely and accurate pathogen identification and susceptibility results that clinicians need to help guide their therapy and patient management decisions.1-6
The BD Phoenix™ M50 System can identify most clinically significant Gram-negative and Gram-positive bacteria, as well as yeast. In addition to accurately confirming known resistance, the BD Phoenix™ M50 Instrument has demonstrated performance in detecting newly emerging resistance to antimicrobials in microorganisms that historically have been susceptible.1,2
Onboard the BD Phoenix™ M50 System today and empower your antimicrobial stewardship teams with the timely, accurate, and actionable information they need to optimize antimicrobial therapy and patient outcomes, and to help stop the spread of antimicrobial resistance.1-7
Timely, accurate microorganism identification and susceptibility testing
The BD Phoenix™ M50 System uses a unique dual growth detection technology, combining an oxidation-reduction indicator and a turbidity measure for more accurate antimicrobial susceptibility results.1
In addition, the BD Phoenix™ M50 System employs a delayed growth algorithm that defers reporting for slow-growing organisms until additional instrument readings are collected, which provides additional assurance that results are accurate.1
On-panel true doubling dilutions
The BD Phoenix™ M50 System utilizes on-panel true doubling dilutions of antimicrobial concentrations to determine minimum inhibitory concentration (MIC)-based susceptibility results for most clinically significant Gram-negative and Gram-positive bacteria.
Antimicrobial resistance markers include* methicillin-resistant Staphylococcus aureus (MRSA), mecA-mediated resistance, vancomycin-resistant S. aureus (VRSA) and Enterococcus spp., vancomycin-resistant S. aureus (VRSA) and Enterococcus spp. (VRE), extended-spectrum β-lactamase (ESBL)-producing organism, high-level aminoglycoside resistant (HLAR) Enterococcus and Streptococcus spp., carbapenemase-producing organism (CPO), and inducible clindamycin resistance (iMLSb).
Detection of emerging resistance
Susceptibility testing for emerging resistance detection and extended MIC ranges to meet CLSI breakpoint guidelines often requires multiple offline tests that can reduce lab efficiency and increase costs.4,8
The BD Phoenix™ M50 System uses dual growth detection technology and innovative panel design with a wide range of antibiotics, extended dilutions, and multiple resistance detection algorithms to provide the foundation for the detection of emerging resistance.1
Learn more about the BD Phoenix™ Emerge Panels.
Modularity and ease-of-use
The BD Phoenix™ M50 Instrument offers a compact and stackable design (up to two instruments) that allows for increased testing volumes by doubling capacity within the same footprint. Furthermore, the system requires no reagent additions post inoculation and few supplemental tests for final result determination, while utilizing leak-resistant, room-temperature panel storage.
The BD Phoenix™ AP automated inoculum preparation instrument can be combined with the BD Phoenix™ M50 System to help reduce sample preparation workflow burden.9,10
Robust, customizable data management
Monitoring, analyzing and communicating microbiology data in a timely manner can directly impact patient care. However, obtaining, organizing and communicating this information is labor intensive.11,12 To provide timely, optimized care and pursue consistent data-driven improvements to emerging antimicrobial resistance and healthcare-associated infections, clinicians need rapid, real-time access to relevant diagnostic data.13
The BD EpiCenter™ Microbiology Data Management System interfaces with the BD Phoenix™ M50 Instrument and provides intuitive, on-demand antibiogram generation, as well as custom alerts for critical results (e.g., CPO, VRSA, ESBL) to support infection prevention and antimicrobial stewardship initiatives.14
Bloodstream Infection Solution
BD Clinical and Lab Support
- The BD Phoenix™ M50 system instrument offers identification-only panels and combination ID/AST panels, using 51 wells for identification substrates.
- The system can provide rapid identification of most clinically significant Gram-negative and Gram- positive bacteria, as well as yeast.
- The BD Phoenix™ M50 system offers 85 wells for antimicrobial dilutions on standard AST-only panels and combination ID/AST panels, and 136 wells on the BD Phoenix™ Emerge™ panel.
- The instrument can provide rapid susceptibility results for most clinically significant Gram-negative and Gram-positive bacteria.
- The BD Phoenix™ M50 system panels test for several resistance markers*such as**:
- Gram-positive bacteria
- HLAR—High Level Aminoglycoside Resistant Enterococcus
- iMLSb—Inducible Clindamycin Resistance
- MRSA—based on Oxacillin Interpretation with Staphylococcus species
- mecA – detection of mecA-medicated resistance in Staphylococcus aureus
- BL- Staphylococcus ß-Lactamase (Nitrocefin based test)
- VRSA—Vancomycin-Resistant Staphylococcus Aureus
- VRE—based on Vancomycin interpretation
- Gram-negative bacteria
- CPO—Carbapenemase Producing Organism
- ESBL—offered on Gram-negative panels and requires no additional disc diffusion or E-Test confirmation.
- Gram-positive bacteria
* Depending on BD Phoenix™ panel type and organism identification
- The BD Phoenix™ CPO detect test, available on certain BD Phoenix™ Gram-negative panels, provides information, including Ambler classification, to help guide clinicians in their treatment decisions.
- This test is available in two-panel configurations that allow microbiology labs to test for CPOs as part of routine susceptibility testing on BD Phoenix™ panels:
- 2-well configuration—provides detection of Carbapenemase-producing organisms in Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter baumannii
- 9-well configuration—provides detection of carbapenemase-producing organisms and Ambler classification (A, B or D) in Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter baumannii
- The BD Phoenix™ CPO detect test is currently the only phenotypic test on an automated AST system that provides CPO detection and Ambler classification.
- On average, the BD Phoenix™ CPO detect test detects and classifies CPOs from isolated colonies within 6 to 11 hours.**
**BD internal studies—data on file
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- BD Phoenix™ M50 Automated Microbiology System User's Manual (500008930).
- Carey RB et al. Failure of Automated Systems to Detect Vancomycin-Resistant Staphylococcus aureus. Abstract presented at the Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Washington, DC, 2004.
- Tenover FC et al. Emerg Infect Dis. 2006;12(8):1209–13.
- Kulah C et al. BMC Infect Dis. 2009;9:30.
- Mittman SA et al. J Clin Microbiol. 2009;47(11):3557–61.
- Woodford N et al. J Clin Microbiol. 2010;48(8):2999–3002.
- Kadri SS et al. Lancet Infect Dis. 2021;21(2):241–51.
- Simner PJ et al. Open Forum Infect Dis. 2022;9(3):ofac007.
- Junkins A et al. J. Clin. Microbiol. 2010;48(5):1929–31.
- Jungkind D et al. Workflow evaluation of the BD Phoenix™ AP Compared to the MicroScan Walkaway overnight system for identification and susceptibility testing of bacteria. Poster presented at the 110th General Meeting of the American Society of Microbiology. May 2010. Study was supported by grants from BD Diagnostic Systems.
- CDC. Preventing Adult Blood Culture Contamination: A Quality Tool for Clinical Laboratory Professionals. Available at: https://www.cdc.gov/labquality/docs/BCC-Prevention_A-Quality-Tool_CDC.pdf. Accessed October 2023.
- Khare R et al. Clin Infect Dis. 2020;70(2):262–8.
- Haque M et al. Risk Manag Healthc Policy. 2020;13:1765–80.
- BD EpiCenter™ Microbiology Data Management System User's Training Manual (SHQ-TM-020).
- BD™ Bruker MALDI Biotyper CA System User Manual (8603291).
- Saffert RT et al. J Clin Microbiol. 2011;49(3):887–92.
- Knabl L et al. Lett Appl Microbiol. 2021;73(1):2–8.
- Watanabe N et al. J Infect Chemother. 2022;28(4):563–8.
- Accelerate PhenoTest BC kit Instructions for Use (LBL000172).
- Almuhayawi M et al. PLoS One. 2015;10(11):e0142398.
*Non-exhaustive list. Depending on BD Phoenix™ panel type and organism identification.