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BD Nexiva Diffusics™ Catheter System

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BD Nexiva™ Diffusics™ Closed IV Catheter System

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Designed With CT Scans in Mind

Address common IV challenges encountered during CT scans

The unique diffusion tip of BD Nexiva Diffusics™
Closed IV Catheter System adds three laser-cut teardrop holes around the catheter tip. It can accommodate power injection up to 325 psi and meet high flow injection protocols.*

Nexiva Diffusics™ Catheter System is built on the Nexiva platform and is specifically designed to address the infusion challenges of contrast-enhanced CT.

*22 G up to 6.5 mL/sec

Common CT Infusion Challenges

High flow rates have traditionally required large gauge catheters

Unfortunately, many patients’ vasculature cannot accommodate 18- or even 20-gauge catheters, and using smaller gauge sizes can result in slower flow rates and reduced image quality.

High flow rates may cause catheters to whip around in the vein.

While achieving appropriate flow rates is crucial to image quality, the high flow rates required for power injection during CT may also cause catheters to move or whip around in the vein which may lead to extravasation and could be costly.1,2

Enable higher flow rates with smaller gauges

The Infusion Therapy Standards of Practice recommend placing the smallest-gauge catheter that will accommodate the prescribed therapy and patient need.3

The diffusion tip on Nexiva Diffusics™ Catheter System enables desired contrast media flow rates to be achieved using a smaller gauge catheter† without compromising image quality. This enables clinicians to perform CT scans that require high flow rates when a patient's vasculature cannot accommodate a large catheter (i.e., 18 or 20 gauge).‡,4 

†22–24 gauge

‡Bench test results may not necessarily be indicative of clinical performance.

Reduce the force of contrast delivery

While flow rates of contrast media are important, the delivery force should also be considered. Nexiva Diffusics™ Catheter System’s diffusion tip reduces the force of contrast delivery by up to 48%,§ helping decrease the impact of contrast media on the vessel wall.

§Compared to a non-diffusion-tip catheter. Bench test results may not necessarily be indicative of clinical performance.

Decrease potential catheter motion in vein

High flow rates required for power injection during CT may cause some catheters to move or whip around in the vein. Catheter motion may lead to extravasation, a complication caused by the catheter backing out of the vein.1

Extravasation may be painful for the patient, potentially resulting in tissue damage.3 The average potential liability for a moderate extravasation is $22k and up to $145k for a severe extravasation.2

Nexiva Diffusics™ Catheter System has been shown to reduce the forces that may cause catheter motion in the vein by up to 67%. This reduction in force stabilizes the catheter in the vein, and prevents the whipping, movement and backing out of the vein that may lead to extravasation.1

The videos below show catheter motion and extravasation of a non-diffusion tip catheter compared to the stability that Nexiva Diffusics™ Catheter System provides during power injection.

Power injection through a non-fenestrated catheter: Extravasation

Note that, due to the force of the injection, the catheter tip will slowly move, backing out of the vein until the tip escapes the vein completely and contrast media enters the surrounding tissue.

Power injection through a non-fenestrated catheter: Catheter Motion

Note the catheter stays in the vein, but the forces from the power injection create enough turbulence to cause the catheter tip to whip around within the vein. This creates significant motion, potentially irritating or damaging the vessel wall.

Power injection through Nexiva Diffusics™ Catheter System with fenestrated tip: Stability

 Note the contrast media flows throughout the vasculature, while the catheter remains still.

†Videos are from an animal study. Animal study results may not be indicative of clinical performance.

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Nexiva Diffusics™ Catheter System Portfolio

Nexiva Diffusics™ Catheter System is offered in two single port configurations: with and without BD MaxZero™ Needle-free Connectors.

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References

  1. Boschi R, Rostagno R. Extravasation of antineoplastic agents: prevention and treatments. Pediatric Reports. 2021;4(e28);98-100.
  2. Paice T. Economic impact of an extravasation. an analysis. Imaging Economics. 2007;20(3):14.
  3. Infusion Nurses Society. Infusion therapy standards of practice. J Infus Nurs. 2024.
  4. Johnson PT, Christensen GM, Fishman EK. IV contrast administration with dual source 128-MDCT: a randomized controlled study comparing 18-gauge nonfenestrated and 20-gauge fenestrated catheters for catheter placement success, infusion rate, image quality and complications. Am J Roentgenol. 2014;202(6):1166-70.

BD-22672 (05/24)

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Nexiva Diffusics™ Catheter System for cardiac CTs

The all-in-one closed IV catheter system leverages a fenestrated tip to accommodate power injection at high flow rates (e.g., 6.5 mL/sec for 22 G) and provides higher vascular attenuation for coronary CTA (CCTA) when compared with non-fenestrated catheters at the same flow rates.



Practice guidelines include using a fenestrated peripheral IV catheter (PIVC), ensuring the IV used is rated to administer flow rates required for coronary CTA (e.g., 5–7 mL/s).1

CCTA benefits

  • ensures high risk patients are appropriately triaged to cardiac catheterization1

  • offers rapid evaluation of the degree of coronary stenosis and atherosclerosis1

  • allows significant reduction in time-to-discharge1

CCTA conditions

  • patient

    Appropriate utilization and patient selection1

  • Diffusics

    Requires high contrast media injection flow rates2

Extracting potential clinical and economic value for CCTA includes improving patient outcomes, lowering healthcare costs and preventing unnecessary diagnostic procedures.1

On-Demand Webinar

Watch a free webinar featuring Dr. Wesley T. O’Neal, MD, FACC, Medical Director, Cardiovascular CT Cone Health Heart & Vascular Center of Greensboro NC

The Nexiva Diffusics™ Advantage

Elevate infusion experiences for your patients

Fenestrated catheter in CCTA1,2
<p>Diagnostic, high-quality images</p> <p>Diagnostic, high-quality images</p>

Diagnostic, high-quality images

Expedite triage Expedite triage
Expedite triage
Reduce risk of complications<sup>3</sup> Reduce risk of complications<sup>3</sup>
Reduce risk of complications3
Achieving high diagnostic accuracy with the lowest possible radiation dose requires careful preparation of CTA patients.1 Adequate peripheral IV access is necessary to ensure diagnostic, high-quality images.2


Image quality is affected by the attenuation achieved in MDCT coronary angiography, particularly in the small coronary arteries. Overall diagnostic accuracy improves significantly when higher intracoronary attenuation is achieved.4 Nexiva Diffusics™ Catheter System has been shown to provide higher vascular attenuation for CCTA when compared with non-fenestrated catheters at the same flow rates.*,5,6


Morbid obesity in CCTA

Morbid obesity is a scenario where CCTA may be difficult or non-diagnostic. Strategies to improve image quality include ensuring high-flow IV contrast injections of 6–7 mL/sec.1 Nexiva Diffusics™ Catheter System can accommodate power injection at 6.5 mL/sec for 22 G and up to 15 mL/sec for 18 G.


*The catheter system has been tested at the flow rates noted for contrast media viscosity 27.5 cP(mPa-s). However, due to variations in add-on devices, tubing, contrast media temperature and pressure limit settings, these flow rates may not be achievable.


Acute chest pain in CCTA

CCTA is a proven strategy to safely expedite diagnosis and limit resource utilization for patients presenting with acute chest pain (ACP) in the ED with no known prior coronary artery disease.1




CCTA has established itself as the preferred first-line test for ACP triage in select patients, and is also now recognized as a Class I indication by multiple international professional societies, including the American College of Cardiology, the American College of Radiology, and the European Society of Cardiology.1


Infusion Therapy Standards of Practice state to consider a fenestrated catheter for a contrast-based radiographic study.8 Nexiva Diffusics™ Catheter System is the only peripheral IV catheter with a fenestrated catheter tip specifically designed for power injection.


Nexiva Diffusics™ Catheter System is designed to enable contrast delivery during CT with smaller IV catheters without increasing the risk of complications.


The stabilizing catheter system reduces:



  • Force of contrast delivery by up to 48%*
  • Destabilizing effects that may lead to extravasation3
  • Potential for the catheter to move or whip around in the vein
  • Chance of phlebitis by up to 29%†,7


These factors enable power injection with smaller IV catheters without an increased risk of complications. Nexiva™ Catheter System has also been associated with lower complications in a number of studies.


Clinical evidence


*Compared to a non-diffusion tip catheter. Bench test results may not necessarily be indicative of clinical performance.

†BD Nexiva™ Catheter System with a PTFE catheter demonstrated a 29% reduction in phlebitis rates when compared to an open system. 

Explore Our Portfolio

Nexiva Diffusics™ Catheter System Portfolio

Nexiva Diffusics™ Catheter System is offered in two single port configurations: with and without BD MaxZero™ Needle-free Connectors.

Partner with BD

Together we can elevate care. Our specialists are here to help.  Let's get started.

BD Nexiva Diffusics™ Catheter System
Ready to learn more? Let’s have a conversation.

References

  1. Maroules C, Rybicki F, Ghoshhajra B, et al. 2022 use of coronary computed tomographic angiography for patients presenting with acute chest pain to the emergency department. Journal of Cardiovascular Computed Tomography. 2023;17:146-163. https://doi.org/10.1016/j.jcct.2022.09.003.
  2. Fischer AM, Riffel P, Henzier T, et al. More holes, more contrast? Comparing an 18-gauge non-fenestrated catheter with a 22-gauge fenestrated catheter for cardiac CT. PLoS ONE 15(6):e0234311. https://doi.org/10.1371/journal.pone.0234311
  3. Boschi R, Rostagno R. Extravasation of antineoplastic agents: prevention and treatments. Pediatric Reports. 2021;4(e28);98-100.
  4. Cademartiri F, Mollet N, Lemos P, et al. Higher intracoronary attenuation improves diagnostic accuracy in MDCT coronary angiography. AJR. 2006;187:W430-W433. doi:10.2214/AJR.05.1406
  5. Harraz M, Abouissa A, Kamr W. Closed versus conventional IV catheter in performing coronary CT Angiography. Egyptian Journal of Radiology and Nuclear Medicine. (2020) 51:89. https://doi.org/10.118/s43055-020-00211-4.
  6. Kim JeongJae, Kim Eun Jeong, Hur Jee Hye, et al. The Usefulness of Fenestrated Intravenous Catheters Compared with Nonfenestrated Catheter for Cardiac Multidetector Computed Tomography. J Comput Assist Tomogr. Volume 43, Number 3, May/June 2019.
  7. González López J, Arribi Vilela A, Fernández Del Palacio E, et al. Indwell times, complications and costs of open vs closed safety peripheral intravenous catheters: a randomized study. J Hosp Infect. 2014;86(2):117-126.
  8. Infusion Nurses Society. Infusion therapy standards of practice. J Infus Nurs. 2024.

Clinical evidence

Nexiva Diffusics™ Catheter System is built on the Nexiva™ platform. Nexiva™ has been shown to deliver higher clinician satisfaction, improved clinician safety and a reduction in overall complication rates versus non-integrated, open systems.1–3

The platform is backed by evidence in peer-reviewed journals from as early as 20094 to as recently as 2024.5

Nexiva™ Diffusics Closed IV Catheter System is also backed by peer-reviewed journals and infusion guidelines. Infusion Therapy Standards of Practice state to consider a fenestrated catheter for a contrast-based radiographic study and in coronary CTA.6 Nexiva Diffusics™ Catheter System is the only peripheral IV catheter with a diffusion catheter tip specifically designed for power injection.

Closed IV Catheter System

Comparative 
catheter

Data gathered

Year published

Study type

Journal

Authors

Nexiva Diffusics™Smiths Jelco
ProtectIV®
Plus		Aortic enhancement levels, catheter placement success,
complications, contrast volume, extravasation,
image quality, infusion rate, maximum pressure		2014RCT7American Journal
of Roentgenology		Johnson PT,
Christensen GM, Fishman EK.
Nexiva™VariousCatheter failure, dislodgement, occlusion, phlebitis2024Systematic review/
meta analysis5		Journal of Vascular
Access		Gidaro A, Quici M, Giustivi D, et al.
Nexiva™BD Insyte
Autoguard™		Complications, dislodgement, dwell time, infiltration, 
occlusion, phlebitis		2023RCT8European Journal
of Oncology Nursing		Gerceker GO, 

Yildirim BG, 

Onal A, et al.
Nexiva™B. Braun 
Introcan 
Safety®

BD Insyte 

Autoguard™
Catheter-associated bloodstream infection,
clinician satisfaction, cost savings/utilization reduction,
dwell time, dislodgement/leaking, infiltration/extravasation,
local infection, insertion success, occlusion, phlebitis		2022RCT1Journal of Hospital MedicineRickard CM, 

Larsen E, 

Walker RM, et al.
Nexiva™Smiths Jelco ProtectIV® PlusClinician satisfaction, dwell time, infection, infiltration,
pain, phlebitis		2019Prospective, quasi-experimental9Journal of Infusion
Nursing		Penoyer D, Fowler S, Bennett M
Nexiva™NoneBlood exposure, dislodgement, kinking, leaking,
phlebitis, restarts		2017Observational10Journal of Vascular
Access		deRosenroll A
Nexiva™MedikitBending and kinking, blood exposure, cost savings/utilization reduction, dislodgement, dwell time, extravasation,
insertion success, obstruction, phlebitis		2014Quasi-randomized study11Journal of Vascular
Access		Tamura N, Abe S, Hagimoto K, et al.
Nexiva™
B. Braun
Vasocan® Safety		Catheter-related infection, cost savings/utilization reduction,
dwell time, infiltration/extravasation, insertion success, occlusion, pain, painful hematoma, phlebitis		2014RCT2
Journal of Hospital Infection 		González López J,
Arribi Vilela A, Fernández Del,
Palacio E, et al.
Nexiva™
B. Braun Introcan Safety® 
(non-winged)
with StatLock		Clinician satisfaction, cost savings/utilization reduction, dislodgement, dwell time, infiltration, insertion success,
leaking, phlebitis		2010RCT3Journal of Infusion
Nursing		Bausone-Gazda D, Lefaiver CA,
Walters SA, et al.
Nexiva™
NoneClinician satisfaction, clotting, dislodgement, infiltration, leaking, restarts, securement2009Pre-and post-use survey4Journal of the
Association of
Vascular Access		McNeil E, Hines N, Phariss R

 

Partner with BD

Together we can elevate care. Our specialists are here to help.  Let's get started.

BD Nexiva Diffusics™ Catheter System
Ready to learn more? Let’s have a conversation.

References

  1. Rickard CM, Larsen E, Walker Rachel M, et al. Integrated versus nonintegrated peripheral intravenous catheter in hospitalized adults (OPTIMUM): A randomized controlled trial. J Hosp Med. 2022;1-12.
  2. González López J, Arribi Vilela A, Fernández Del Palacio E, et al. Indwell times, complications and costs of open vs closed safety peripheral intravenous catheters: a randomized study. J Hosp Infect. 2014;86(2):117-126.
  3. Bausone-Gazda D, Lefaiver CA, Walters SA. A randomized controlled trial to compare the complications of 2 peripheral intravenous catheter-stabilization systems. J Infus Nurs. 2010;33(6):371-384.
  4. McNeil E, Hines N, Phariss R. A clinical trial of a new all-in-one peripheral-short catheter. JAVA. 2009;14(1):46-51.
  5. Gidaro A, Quici M, Giustivi D, et al. Integrated short peripheral intravenous cannulas and risk of catheter failure: a systematic meta-analysis. J Vasc Access. 2024.
  6. Infusion Nurses Society. Infusion therapy standards of practice. J Infus Nurs. 2024.
  7. Johnson PT, Christensen GM, Fishman EK. IV contrast administration with dual source 128-MDCT: a randomized controlled study comparing 18-gauge nonfenestrated and 20-gauge fenestrated catheters for catheter placement success, infusion rate, image quality and complications. Am J Roentgenol. 2014;202(6):1166-70.
  8. Gerceker GO, Yildirim BG, Onal A, et al. The effect of the closed intravenous catheter system on first insertion success, indwelling time, and complications in pediatric hematology and oncology patients: a randomized controlled study. Eur J Oncol Nurs. 2023 Dec:67:102430. doi: 10.1016/j.ejon.2023.102430. Epub 2023 Oct 7.
  9. Penoyer D, Fowler S, Bennett M. Evaluation of the Use of Open Versus Closed Short Peripheral Catheters on Catheter Dwell Time. J Infus Nurs. 2019;42(6):276-282.
  10. deRosenroll A. Peripheral intravenous catheters: Improving outcomes through change in products, clinical practice and education. Vasc Access. 2017;11(1):7-12.
  11. Tamura N, Abe S, Hagimoto K, et al. Unfavorable peripheral intravenous catheter replacements can be reduced using an integrated closed intravenous catheter system. J Vasc Access. 2014;15(4):257-263.

BD Nexiva Diffusics™ Catheter System

    Catalog no.

    Color

    Gauge

    Catheter length (in)

    Gravity flow rate
(mL/min)

    Maximum power
    injector pressure limit setting (psi)

    Maximum power
    injector flow rate
    for contrast media viscosity 27.5:
    cP(maPa-s)*

    383590Yellow240.75213253.00 mL/sec
    383591Blue221.00453256.50 mL/sec
    383592Pink201.006832510.00 mL/sec
    383593Pink201.256432510.00 mL/sec
    383594Green181.259032515.00 mL/sec

     

    *The catheter system has been tested at flow rates; however, due to variations in add-on devices, tubing, contrast media temperature and pressure limit settings these flow rates may not be achievable.


    BD Nexiva Diffusics™ Catheter System with BD MaxZero™ Needle-free Connectors

      Catalog no.

      Color

      Gauge

      Catheter
      length (in)

      Catheter
      ID in (mm)

      Catheter
      OD in (mm)

      Extension
      tube ID
      (mm)

      Gravity
      flow rate
      (mL/min)

      Max power
      injector
      flow rate
      for contrast
      media viscosity
      27.5 cP (mPa-s)*
      (mL/sec)

      Packaging

      383595Yellow24.750.0210
      (0.53)      		0.0280
      (0.71)      		1.22213.020/box 80/
      case
      383596Blue221.000.0265
      (0.67)      		0.0355
      (0.90)      		1.22456.520/box 80/
      case
      383598Blue221.750.0265
      (0.67)      		0.0355
      (0.90)      		1.65335.020/box 80/
      case
      383597Pink201.000.0325
      (0.83)      		0.0435
      (1.10)      		1.656810.020/box 80/
      case
      383587Pink201.250.0325
      (0.83)      		0.0435
      (1.10)      		1.656410.020/box 80/
      case
      383599Pink201.750.0325
      (0.83)      		0.0435
      (1.10)      		1.65538.520/box 80/
      case
      383588Green181.250.0385
      (0.98)      		0.0515
      (1.31)      		1.659015.020/box 80/
      case
      393589Green181.750.0385
      (0.98)      		0.0515
      (1.31)      		1.658411.020/box 80/
      case

       

      *The catheter system has been tested at flow rates; however, due to variations in add-on devices, tubing, contrast media temperature and pressure limit settings these flow rates may not be achievable.

      Partner with BD

      Together we can elevate care. Our specialists are here to help.  Let's get started.

      BD Nexiva Diffusics™ Catheter System
      Ready to learn more? Let’s have a conversation.

      References

      1. Infusion Nurses Society. Infusion therapy standards of practice. J Infus Nurs. 2024.
      2. Williams A. Catheter Occlusion in Home Infusion: The influence of needleless connector design on central catheter occlusion. J Infus Nurs. 2018;41(1):52-57. Doi: 10.1097/NAN.0000000000000259.
      3. Bausone-Gazda D, Lefaiver CA, Walters SA. A randomized controlled trial to compare the complications of 2 peripheral intravenous catheter-stabilization systems. J Infus Nurs. 2010;33(6):371-384.
      4. González López J, Arribi Vilela A, Fernández Del Palacio E, et al. Indwell times, complications and costs of open vs closed safety peripheral intravenous catheters: a randomized study. J Hosp Infect. 2014;86(2):117-126.
      5. Kus B, Buyukyilmaz F. Effectiveness of Vialon biomaterial versus Teflon catheters for peripheral intravenous placement: A randomized clinical trial. Jpn J Nurs Sci. 2020;e12328. https://doi.org/10.1111/jjns.12328.
      6. Maki DG, Ringer M. Risk factors for infusion-related phlebitis with small peripheral venous catheters. Ann Intern Med. 1991;114(10):845-854.
      7. Gaukroger PB, Roberts JG, Manners TA. Infusion thrombophlebitis: a prospective comparison of 645 Vialon and Teflon cannulae in anaesthetic and postoperative use. Anaesthetic and Intensive Care. 1988;16:265-271.
      8. van Loon FHG, Timmerman R, den Brok GPH, et al. The impact of a notched peripheral intravenous catheter on the first attempt success rate in hospitalized adults: block randomized trial. JVA. 2021 doi: 10.1177/1129729821990217.
      9. Seetharam AM, Raju U, Suresh K. A randomized controlled study to compare first stick success with Instaflash technology: The FIRSST study. JVA. 2022 doi:10.1177/11297298221080369.

      Partner with BD

      Together we can elevate care. Our specialists are here to help.  Let's get started.

      BD Nexiva Diffusics™ Catheter System
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      Together we can elevate care. Our specialists are here to help.  Let's get started.

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      Ready to learn more? Let’s have a conversation.
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